The hypothalamo-pituitary-adrenocortical (HPA axis) is required for stress adaptation. Activation of the HPA axis causes secretion of glucocorticoids, which act on multiple organ systems to redirect energy resources to meet real or anticipated demand.
Chronic stress-induced activation of the HPA axis takes many forms (chronic basal hypersecretion, sensitized stress responses, even adrenal exhaustion), with manifestation dependent upon factors such as stressor chronicity, intensity, frequency and modality.
Chronic stress leads to reduced sensitivity of the negative feedback system that governs the hypothalamic-pituitary-adrenal (HPA) axis. The loss of this negative feedback system is due to an increased level of circulating glucocorticoids (GCs). HPA axis dysregulation results in downstream physiological consequences, increasing risk for immune system dysfunction, mood disorders, metabolic disease, and cardiovascular disease.
Almost all the diseases are governed by the level of stress we are having: Chronic myofascial pain is one such common stress that is killing us with time. Don't ignore your stress/Pain, it can work as a trigger for any lifestyle/Metabolic/Musculoskeletal /Cancer in your body.
Live life free from pain & stress.